EARLY PREDICTORS OF GESTATIONAL TROPHOBLASTIC NEOPLASIA
Keywords:gestational trophoblastic disease, hydatidiform mole, choriocarcinoma, immunohistochemistry, CLIC-1
This study evaluated the expression of the CLIC-1 protein by immunohistochemical method in gestational trophoblastic disease, as well as its diagnostic value in predicting the malignant process. The study included 71 patients with gestational trophoblastic disease. There were higher levels of CLIC-1 immunoreactivity in trophoblastic cells in patients with gestational trophoblastic neoplasia compared with patients with hydatidiform mole. Thus, CLIC-1 can serve as a prognostic marker that allows detecting malignant transformation at an early stage.